(S)-(+)-O-Desmethyl Venlafaxine

• 常用名: (S)-(+)-O-Desmethyl Venlafaxine
• 英文名: (S)-(+)-O-Desmethyl Venlafaxine
• CAS号: 142761-12-4
• 分子量: 263.37500
• 密度: 1.115g/cm3
• 沸点: 403.792ºC at 760 mmHg
• 分子式: C₁₆H₂₅NO₂
• 熔点: 208-213ºC
• 闪点: 193.192ºC

(S)-(+)-O-Desmethyl Venlafaxine用途

(S)-(+)-O-Desmethyl Venlafaxine 是 O-Desmethyl Venlafaxine 的 S-对映异构体。O-Desmethyl Venlafaxine 是 Venlafaxine 的活性代谢产物。Venlafaxine (HY-B0196) 是 5-羟色胺-去甲肾上腺素再摄取抑制剂 (SNRI) 类的抗抑郁剂。

(S)-(+)-O-Desmethyl Venlafaxine名称

• 中文名: S-(+)-O-去甲基文拉法辛
• 英文名: S-(+)-O-Desmethyl Venlafaxine

(S)-(+)-O-Desmethyl Venlafaxine生物活性

• 描述: (S)-(+)-O-Desmethyl Venlafaxine 是 O-Desmethyl Venlafaxine 的 S-对映异构体。O-Desmethyl Venlafaxine 是 Venlafaxine 的活性代谢产物。Venlafaxine (HY-B0196) 是 5-羟色胺-去甲肾上腺素再摄取抑制剂 (SNRI) 类的抗抑郁剂。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Yijin Liu, et al. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. J Chromatogr A. 2015 Nov 13;1420:119-28.

  [2]. F P Bymaste, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

(S)-(+)-O-Desmethyl Venlafaxine物理化学性质

• 密度: 1.115g/cm3
• 沸点: 403.792ºC at 760 mmHg
• 熔点: 208-213ºC
• 分子式: C₁₆H₂₅NO₂
• 分子量: 263.37500
• 闪点: 193.192ºC
• 精确质量: 263.18900
• PSA: 43.70000
• LogP: 2.73260
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.573
• 储存条件: 2-8°C，密封，干燥

(S)-(+)-O-Desmethyl Venlafaxine英文别名

• 4-[(1S)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol