ZANAMIVIR HYDRATE

• 常用名: ZANAMIVIR HYDRATE
• 英文名: ZANAMIVIR HYDRATE
• CAS号: 171094-50-1
• 分子量: 350.325
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₂₂N₄O₈
• 熔点: N/A
• 闪点: N/A

ZANAMIVIR HYDRATE用途

水合扎那米韦(5:1)是扎那米威的水合物。扎那米韦是一种流感病毒神经氨酸酶抑制剂,对甲型和乙型流感的IC50值分别为0.95 nM和2.7 nM[1]。

ZANAMIVIR HYDRATE名称

• 英文名: ZANAMIVIR HYDRATE

ZANAMIVIR HYDRATE生物活性

• 描述: 水合扎那米韦(5:1)是扎那米威的水合物。扎那米韦是一种流感病毒神经氨酸酶抑制剂,对甲型和乙型流感的IC50值分别为0.95 nM和2.7 nM[1]。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 靶点:

  IC50: 0.95 nM (Influenza A); 2.7 nM (Influenza B)[1]

• 体内研究: 扎那米韦口服给药的生物利用度较差,只有4-17%的药物。扎那米韦的口服给药一直是一个问题,因为其强亲水性限制了其在肠上皮的转运。渗透促进剂如胆酸钠、羟丙基β-环糊精可与扎那米韦一起使用,以增强肠道通透性[3]。
• 参考文献:

  [1]. Gubareva LV, et al. Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates ofinfluenza virus and neuraminidase inhibitor-resistant variants. Antimicrob Agents Chemother. 2001 Dec;45(12):3403-8.

  [2]. McKimm-Breschkin JL, et al. Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir Med. 2005;4(2):107-16.

  [3]. Shanmugam S, et al. Zanamivir oral delivery: enhanced plasma and lung bioavailability in rats. Biomol Ther (Seoul). 2013 Mar;21(2):161-9.

ZANAMIVIR HYDRATE物理化学性质

• 分子式: C₁₂H₂₂N₄O₈
• 分子量: 350.325
• 精确质量: 350.143768

ZANAMIVIR HYDRATE英文别名

• D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-, hydrate (1:1)
• ZANAMIVIR HYDRATE
• D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-, hydrate (5:1)
• MFCD03791324
• (6R)-5-Acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-L-threo-hex-2-enonic acid hydrate (1:1)