缬更昔洛韦盐酸盐

• 常用名: 缬更昔洛韦盐酸盐
• 英文名: Valganciclovir Hydrochloride
• CAS号: 175865-59-5
• 分子量: 390.823
• 密度: N/A
• 沸点: 629.1ºC at 760 mmHg
• 分子式: C₁₄H₂₃ClN₆O₅
• 熔点: N/A
• 闪点: N/A

缬更昔洛韦盐酸盐用途

Valganciclovir盐酸盐是ganciclovir的原药,具有抗巨细胞病毒活性。

缬更昔洛韦盐酸盐名称

• 中文名: 缬更昔洛韦盐酸盐
• 英文名: Valganciclovir hydrochloride
• 中文别名: 马来酸茚达特罗 | 盐酸缬更昔洛韦 | (S)-2-氨基-3-甲基丁酸 (R,S)-2-[(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)甲氧基]-3-羟基丙酯盐酸盐

缬更昔洛韦盐酸盐生物活性

• 描述: Valganciclovir盐酸盐是ganciclovir的原药,具有抗巨细胞病毒活性。
• 相关类别:
  信号通路 >> 抗感染 >> CMV
  研究领域 >> 感染
• 参考文献:

  [1]. Sugawara M, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9.

  [2]. Chawla JS, et al. Oral valganciclovir versus ganciclovir as delayed pre-emptive therapy for patients after allogeneic hematopoietic stem cell transplant: a pilot trial (04-0274) and review of the literature. Transpl Infect Dis. 2012 Jun;14(3):259-67.

  [3]. O'Brien S, et al. Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy. Blood. 2008 Feb 15;111(4):1816-9.

缬更昔洛韦盐酸盐物理化学性质

• 沸点: 629.1ºC at 760 mmHg
• 分子式: C₁₄H₂₃ClN₆O₅
• 分子量: 390.823
• 精确质量: 390.141846
• PSA: 171.37000
• LogP: 0.64680
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 1.08E-16mmHg at 25°C
• 储存条件: -20°C
• 水溶解性: 水溶性：可溶；可溶于：二甲基甲酰胺,甲醇；极微溶：乙醇

缬更昔洛韦盐酸盐安全信息

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport

缬更昔洛韦盐酸盐英文别名

• (2S)-2-amino-3-méthylbutanoate de 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)méthoxy]-3-hydroxypropyle chlorhydrate
• L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
• L-valine, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride
• 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate hydrochloride
• 2-[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl-(2S)-2-amino-3-methylbutanoathydrochlorid
• Valganciclovir Hydrochloride
• Valganciclovir HCl
• 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate hydrochloride (1:1)
• L-Valine, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
• 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate hydrochloride
• L-Valine (2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester
• Valganciclovir (hydrochloride)