ONO 1301

更新时间：2024-01-02 11:34:18

ONO 1301结构式	常用名	ONO 1301	英文名	ONO 1301
	CAS号	176391-41-6	分子量	428.48000
	密度	N/A	沸点	N/A
	分子式	C₂₆H₂₄N₂O₄	熔点	147-158 °C
	MSDS	中文版美版	闪点	N/A

ONO 1301用途

ONO 1301(ONO-AP 500-02)是一种前列腺素(PG)I2模拟物,是一种口服活性长效前列环素激动剂,具有血栓素合酶抑制活性。ONO 1301促进不同细胞类型肝细胞生长因子(HGF)的产生,并改善缺血诱导的小鼠、大鼠和猪的左心室功能障碍[1][2][3]。

英文名	ono-1301
英文别名	更多

描述	ONO 1301(ONO-AP 500-02)是一种前列腺素(PG)I2模拟物,是一种口服活性长效前列环素激动剂,具有血栓素合酶抑制活性。ONO 1301促进不同细胞类型肝细胞生长因子(HGF)的产生,并改善缺血诱导的小鼠、大鼠和猪的左心室功能障碍[1][2][3]。
相关类别	研究领域 >> 心血管疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
体外研究	ONO 1301(ONO-AP 500-02)以浓度依赖的方式抑制胶原诱导的聚集,IC50值为460nm[3]。ONO-1301(0-1000 nM)显著增加原代成骨细胞和ST2细胞中的碱性磷酸酶(ALP)活性[3]。
体内研究	ONO-1301(6 mg/kg；p.o.；/天,持续4周)改善实验性自身免疫性心肌炎后扩张型心肌病大鼠的血流动力学状态[1]。动物模型：8周龄雄性Lewis大鼠(肌球蛋白诱导的实验性自身免疫性心肌炎大鼠模型)[1]剂量：6mg/kg给药：口服/结果：血流动力学参数和血浆脑钠肽(BNP)水平均明显改善。
参考文献	[1]. Hirata Y, et al. Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model. Eur J Pharmacol. 2013;699(1-3):81-87. [2]. Kashiwagi H, et al. The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an antiplatelet effect due to its inhibitory action on thromboxane A2 synthesis in mice. J Pharmacol Exp Ther. 2015;353(2):269-278. [3]. Kanayama S, et al. ONO-1301 Enhances in vitro Osteoblast Differentiation and in vivo Bone Formation Induced by Bone Morphogenetic Protein. Spine (Phila Pa 1976). 2018;43(11):E616-E624.

熔点	147-158 °C
分子式	C₂₆H₂₄N₂O₄
分子量	428.48000
精确质量	428.17400
PSA	81.01000
LogP	4.73390
外观性状	固体
储存条件	-20° C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

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