组蛋白脱乙酰酶抑制剂

更新时间：2024-01-02 17:50:28

组蛋白脱乙酰酶抑制剂结构式	常用名	组蛋白脱乙酰酶抑制剂	英文名	Apicidin
	CAS号	183506-66-3	分子量	609.75600
	密度	1.27g/cm3	沸点	N/A
	分子式	C₃₄H₄₉N₅O₆	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS06	信号词	Danger

组蛋白脱乙酰酶抑制剂用途

Apicidin (OSI 2040) 是真菌的代谢物, 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂,具有抗寄生虫活性和广谱的抗增殖活性。

中文名	组蛋白脱乙酰酶抑制剂
英文名	(3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone
英文别名	更多

描述	Apicidin (OSI 2040) 是真菌的代谢物, 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂,具有抗寄生虫活性和广谱的抗增殖活性。
相关类别	研究领域 >> 癌症研究领域 >> 感染信号通路 >> 细胞周期/DNA损伤 >> HDAC 信号通路 >> 表观遗传学 >> HDAC
靶点	HDAC[1]
参考文献	[1]. Han JW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000 Nov 1;60(21):6068-74.

密度	1.27g/cm3
分子式	C₃₄H₄₉N₅O₆
分子量	609.75600
精确质量	609.35300
PSA	138.84000
LogP	4.12130
外观性状	固体
折射率	1.615

符号	GHS06
信号词	Danger
危害声明	H300-H310-H330
警示性声明	P260-P264-P280-P284-P302 + P350-P310
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T+: Very toxic;
风险声明 (欧洲)	R26/27/28
安全声明 (欧洲)	22-26-36/37/39-45
危险品运输编码	UN 2811 6.1/PG 2

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Acipidin

(3S,6S,9S,15aR)-9-[(2S)-Butan-2-yl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone

2H-Pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone, octahydro-6-[(1-methoxy-1H-indol-3-yl)methyl]-9-[(1S)-1-methylpropyl]-3-(6-oxooctyl)-, (3S,6S,9S,15aR)-

OSI-2040

(3S,6S,9S,15aR)-9-(butan-2-yl)-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone

(3S,6S,9S,15aR)-9-[(2S)-2-Butanyl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone

Apicidin