PPOH

更新时间：2024-01-06 18:06:40

PPOH结构式	常用名	PPOH	英文名	PPOH
	CAS号	206052-01-9	分子量	246.302
	密度	1.1±0.1 g/cm3	沸点	411.0±40.0 °C at 760 mmHg
	分子式	C₁₅H₁₈O₃	熔点	N/A
	MSDS	中文版美版	闪点	151.1±20.8 °C

PPOH用途

PPOH是一种脂肪酸衍生物,是一种选择性环氧合酶(COX)抑制剂,可抑制肾皮质微粒体中的花生四烯酸环氧合酶活性。此外,PPOH作用于CYP4A2和CYP4A3,IC50值分别为22μM和6.5μM[1]。

英文名	6-(2-Propargyloxyphenyl)hexanoic acid
英文别名	更多

描述	PPOH是一种脂肪酸衍生物,是一种选择性环氧合酶(COX)抑制剂,可抑制肾皮质微粒体中的花生四烯酸环氧合酶活性。此外,PPOH作用于CYP4A2和CYP4A3,IC50值分别为22μM和6.5μM[1]。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450 研究领域 >> 其他信号通路 >> 免疫及炎症 >> COX
体外研究	PPOH(5μM)在不存在和存在30分钟NADPH预培养的情况下可分别抑制CYP2C9活性63%和90%,而在30分钟预培养中不存在NADPH时可抑制63%[1]。
参考文献	[1]. Melissa A VanAlstine, et al. Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450s. Drug Metab Dispos. 2011 Jul;39(7):1221-6.

密度	1.1±0.1 g/cm3
沸点	411.0±40.0 °C at 760 mmHg
分子式	C₁₅H₁₈O₃
分子量	246.302
闪点	151.1±20.8 °C
精确质量	246.125595
PSA	46.53000
LogP	3.05
蒸汽压	0.0±1.0 mmHg at 25°C
折射率	1.534
储存条件	-20°C，密闭，干燥

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	22-24/25
危险品运输编码	NONH for all modes of transport
海关编码	2918990090

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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