Photoswitchable PAD inhibitor

• 常用名: Photoswitchable PAD inhibitor
• 英文名: Photoswitchable PAD inhibitor
• CAS号: 2226393-62-8
• 分子量: 487.984
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₆H₂₆ClN₇O
• 熔点: N/A
• 闪点: N/A

Photoswitchable PAD inhibitor用途

Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination.

Photoswitchable PAD inhibitor名称

• 英文名: N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-[(E)-phenyldiazenyl]benzamide

Photoswitchable PAD inhibitor物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₆H₂₆ClN₇O
• 分子量: 487.984
• 精确质量: 487.188751
• LogP: 4.19
• 折射率: 1.672

Photoswitchable PAD inhibitor英文别名

• Benzamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4-[(E)-2-phenyldiazenyl]-
• N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-[(E)-phenyldiazenyl]benzamide