FG-2216

• 常用名: FG-2216
• 英文名: FG-2216
• CAS号: 223387-75-5
• 分子量: 280.66400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₉ClN₂O₄
• 熔点: N/A
• 闪点: N/A

FG-2216用途

FG-2216是HIF-PHD抑制剂，IC50值为3.9uM。

FG-2216名称

• 中文名: [[(1-氯-4-羟基异喹啉-3-基)羰基]氨基]乙酸
• 英文名: [[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid

FG-2216生物活性

• 描述: FG-2216是HIF-PHD抑制剂,IC50值为3.9uM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶
  研究领域 >> 其他
• 参考文献:

  [1]. Hong YR, et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7.

  [2]. Hsieh MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7.

FG-2216物理化学性质

• 分子式: C₁₂H₉ClN₂O₄
• 分子量: 280.66400
• 精确质量: 280.02500
• PSA: 99.52000
• LogP: 1.79910
• 外观性状: 粉末
• 储存条件: -20℃

FG-2216英文别名

• [(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]acetic acid
• [(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid
• [(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid
• (N-(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino)-acetic acid
• Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-
• N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine
• N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine
• FG-2216
• [(1chloro-4-hydroxy-isoquinoline-3-carbonyl)amino]-acetic acid
• FG2216