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N-去甲盐酸多塞平

更新时间:2024-01-08 00:10:34

N-去甲盐酸多塞平结构式
N-去甲盐酸多塞平结构式
品牌特惠专场
常用名 N-去甲盐酸多塞平 英文名 nordoxepin
CAS号 2887-91-4 分子量 265.350
密度 1.1±0.1 g/cm3 沸点 420.8±44.0 °C at 760 mmHg
分子式 C18H20ClNO 熔点 159-160ºC
MSDS 中文版 美版 闪点 174.5±17.9 °C
符号 GHS07 GHS09
GHS07, GHS09
信号词 Warning

 N-去甲盐酸多塞平用途


盐酸诺多西平是多塞平的主要代谢产物。多塞平是一种三环类抗抑郁药,广泛用于治疗轻度抑郁症[1]。

 N-去甲盐酸多塞平名称

中文名 去甲多塞平 盐酸盐
英文名 Nordoxepin Hydrochloride
中文别名 11[6h]-[3-(甲基氨基)亚丙基]二苯[b,e]多虑平盐酸盐
英文别名 更多

 N-去甲盐酸多塞平生物活性

描述 盐酸诺多西平是多塞平的主要代谢产物。多塞平是一种三环类抗抑郁药,广泛用于治疗轻度抑郁症[1]。
相关类别
参考文献

[1]. Negrusz A, et al. Detection of doxepin and its major metabolite desmethyldoxepin in hair following drug therapy. J Anal Toxicol. 1998;22(6):531-536.

 N-去甲盐酸多塞平物理化学性质

密度 1.1±0.1 g/cm3
沸点 420.8±44.0 °C at 760 mmHg
熔点 159-160ºC
分子式 C18H20ClNO
分子量 265.350
闪点 174.5±17.9 °C
精确质量 265.146667
PSA 21.26000
LogP 4.59
外观性状 powder | white to off-white
蒸汽压 0.0±1.0 mmHg at 25°C
折射率 1.635
储存条件 -20°C Freezer

 N-去甲盐酸多塞平MSDS

 N-去甲盐酸多塞平安全信息

符号 GHS07 GHS09
GHS07, GHS09
信号词 Warning
危害声明 H302-H400
警示性声明 P273
危害码 (欧洲) Xn,N
风险声明 (欧洲) 22-50/53
安全声明 (欧洲) 60-61
危险品运输编码 UN 3077 9 / PGIII
WGK德国 3

 N-去甲盐酸多塞平文献26

更多文献
Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(27) , 3025-30, (2009)

Perhexiline is a drug that is used for treatment of moderate to severe angina pectoris that has not responded to other treatment. It has a low therapeutic index, and saturable metabolism that is also ...

Simultaneous determination of doxepin and nordoxepin in serum using high-performance liquid chromatography.

J. Chromatogr. A. 419 , 445-51, (1987)

Quantitative determination of E- and Z-doxepin and E- and Z-desmethyldoxepin by high-performance liquid chromatography.

Ther. Drug Monit. 17(4) , 371-6, (1995)

A high-performance liquid chromatographic (HPLC) method was developed for the quantitative, simultaneous determination of the following four compounds in serum: E-doxepin, Z-doxepin, E-desmethyldoxepi...

 N-去甲盐酸多塞平英文别名

(3Z)-3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N-methylpropan-1-amine
3-Dibenz(b,e)oxepin-11(6H)-ylidene-N-methyl-1-propanamine
1-Propanamine,3-dibenzb,eoxepin-11(6H)-ylidene-N-methyl-,hydrochloride
11[6H]-[3-(METHYLAMINO)PROPYLIDENE]DIBENZ[B,E]OXEPINE HYDROCHLORIDE
nordoxepin
N-DesMethyldoxepin-d3 Hydrochloride
1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N-methyl-, (3Z)-
11(6h)-(3-[methylamino]propylidene)dibenz[b,e]oxepine
1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N-methyl-
NorDoxepinHydrochloride
(3Z)-3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N-methyl-1-propanamine
3-Dibenzo[b,e]oxepin-11(6H)-ylidene-N-methylpropan-1-amine
demethyldoxepin
3-(Dibenz[b,e]oxepin-11(6H)-ylidene)-N-Methyl
N-Desmethyldoxepin
N-DesMethyldoxepin Hydrochloride
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