[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

• 常用名: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
• 英文名: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
• CAS号: 313988-89-5
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈₃H₂₈₀N₅₇O₅₄S₂
• 熔点: N/A
• 闪点: N/A

用途

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 是一种有效的,选择性神经肽 YY5 受体激动剂,与 hY5 受体结合的 IC50 值为 0.24 nM。[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 增加饮食摄入量。

名称

• 中文名: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-胰多肽
• 英文名: (4S)-4-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]-5-oxo-pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxy-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-carboxy-propanoyl]amino]-4-oxo-butanoyl]amino]propanoyl]amino]-3-hydroxy-butanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(1S)-4-amino-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S,2S)-1-[[(1S)-3-amino-1-[[(1S)-1-[[(1S)-2-[[2-[[(1S)-1-[[(1S)-4-amino-1-[[(1S)-1-[[(1S)-2-amino-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-4-oxo-butyl]carbamoyl]-4-guanidino-butyl]amino]-1,1-dimethyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-4-oxo-butyl]amino]-5-oxo-pentanoic acid

生物活性

• 描述: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 是一种有效的,选择性神经肽 YY5 受体激动剂,与 hY5 受体结合的 IC50 值为 0.24 nM。[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 增加饮食摄入量。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体
• 靶点:

  hY5 receptor:0.24 nM (IC50)

  hY1 receptor:530 nM (IC50)

  hY2 receptor:>500 nM (IC50)

  hY4 receptor:51 nM (IC50)

• 体外研究: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide具有530nm,>500nm,51nm的IC50s,用于与hY1,hY4,hY2受体结合[1]。
• 体内研究: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide(0.2,2nmol/rate)诱导体重为340-400g的成年雄性大鼠大量进食[1]。
• 参考文献:

  [1]. C Cabrele , et al. The first selective agonist for the neuropeptide YY₅ receptor increases food intake in rats. J Biol Chem. 2000 Nov 17;275(46):36043-8.

物理化学性质

• 分子式: C₁₈₃H₂₈₀N₅₇O₅₄S₂

英文别名

• (Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human)