K-毒毛旋花子配质-3-L-鼠李糖甙

更新时间：2024-01-02 17:47:12

K-毒毛旋花子配质-3-L-鼠李糖甙结构式	常用名	K-毒毛旋花子配质-3-L-鼠李糖甙	英文名	CONVALLATOXIN
	CAS号	508-75-8	分子量	550.63800
	密度	1.41 g/cm3	沸点	757.3ºC at 760 mmHg
	分子式	C₂₉H₄₂O₁₀	熔点	235-242ºC
	MSDS	中文版美版	闪点	247.1ºC

K-毒毛旋花子配质-3-L-鼠李糖甙用途

Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物,并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂,具有很高的效力和功效。具有抗炎和抗增殖特性。

中文名	铃兰毒甙
英文名	convallatoxin
中文别名	K-毒毛旋花子配质-3-L-鼠李糖甙 \| 鈴蘭毒
英文别名	更多

描述	Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物,并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂,具有很高的效力和功效。具有抗炎和抗增殖特性。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> PPAR 研究领域 >> 炎症/免疫信号通路 >> 跨膜转运 >> P-糖蛋白
体外研究	铃兰毒素诱导HaCaT细胞坏死(4)。
体内研究	铃兰毒素在两种银屑病小鼠模型中发挥抗银屑病活性〔4〕。
参考文献	[1]. Li MY, et al. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacol Res. 2019 Sep;147:104355. [2]. Gozalpour E, et al. Convallatoxin: a new P-glycoprotein substrate. Eur J Pharmacol. 2014 Dec 5;744:18-27. [3]. Chao PK, et al. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Sci Rep. 2019 Feb 20;9(1):2405. [4]. Jiang BW, et al. Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. Biomed Pharmacother. 2020 Jan;121:109615.

密度	1.41 g/cm3
沸点	757.3ºC at 760 mmHg
熔点	235-242ºC
分子式	C₂₉H₄₂O₁₀
分子量	550.63800
闪点	247.1ºC
精确质量	550.27800
PSA	162.98000
LogP	0.75000
外观性状	淡黄色粉末
折射率	1.622
储存条件	2-8℃，干燥

K-毒毛旋花子配质-3-L-鼠李糖甙MSDS英文版

K-毒毛旋花子配质-3-L-鼠李糖甙毒性英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	UN 3249
WGK德国	2
RTECS号	GL4025000
包装等级	III
危险类别	6.1(b)

2,3,4-三-O-乙酰基-6...

5158-64-5

毒毛旋花子苷元

66-28-4

K-毒毛旋花子配质-3-L-鼠李糖甙

508-75-8

文献：Reyle et al. Helvetica Chimica Acta, 1950 , vol. 33, p. 1541,1545 Anm.1

2,3,4-tri-O-ace...

69980-52-5

毒毛旋花子苷元

66-28-4

K-毒毛旋花子配质-3-L-鼠李糖甙

508-75-8

文献：Makarevich, I. F.; Terno, I. S. Chemistry of Natural Compounds, 1988 , vol. 24, # 3 p. 323 - 325 Khimiya Prirodnykh Soedinenii, 1988 , vol. 24, # 3 p. 383 - 386

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CAS号5158-64-5 2,3,4-三-O-乙酰基-6... CAS号66-28-4 毒毛旋花子苷元 CAS号69980-52-5 2,3,4-tri-O-ace...
K-毒毛旋花子配质-3-L-鼠李糖甙下游产品 0

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CONVALLATOXIN

Convallatoxin