BML-210

更新时间：2024-01-02 08:19:47

BML-210结构式	常用名	BML-210	英文名	BML-210
	CAS号	537034-17-6	分子量	339.431
	密度	1.2±0.1 g/cm3	沸点	632.5±40.0 °C at 760 mmHg
	分子式	C₂₀H₂₅N₃O₂	熔点	N/A
	MSDS	中文版美版	闪点	336.3±27.3 °C

BML-210用途

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BML-210 是一类新颖的HDAC抑制剂，其IC50值为5 μM。

中文名	BML-210
英文名	bml-210
英文别名	更多

描述	BML-210 是一类新颖的HDAC抑制剂,其IC50值为5 μM。
相关类别	研究领域 >> 癌症
靶点	HDAC4:MEF2
参考文献	[1]. Nimanthi Jayathilaka, et al. Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res. 2012 Jul; 40(12): 5378–5388. [2]. Veronika V. Borutinskaite, et al. Histone deacetylase inhibitor BML-210 induces growth inhibitionand apoptosis and regulates HDAC and DAPC complexexpression levels in cervical cancer cells. Mol Biol Rep (2012) 39:10179–10186 [3]. Veronika Borutinskaite, et al. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci. 2015 Aug; 16(8): 18252–18269.

密度	1.2±0.1 g/cm3
沸点	632.5±40.0 °C at 760 mmHg
分子式	C₂₀H₂₅N₃O₂
分子量	339.431
闪点	336.3±27.3 °C
精确质量	339.194672
PSA	84.22000
LogP	2.58
外观性状	white solid
蒸汽压	0.0±1.9 mmHg at 25°C
折射率	1.633
储存条件	-20℃

危害声明	H413
危险品运输编码	NONH for all modes of transport

The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming.

Int. J. Mol. Sci. 16 , 18252-69, (2015)

Today, cancer is understood as an epigenetic as well as genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. Proteins such as histone deacet...

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