丙酸倍氯米松

更新时间：2024-01-04 03:12:26

丙酸倍氯米松结构式	常用名	丙酸倍氯米松	英文名	Beclometasone dipropionate
	CAS号	5534-09-8	分子量	521.042
	密度	1.3±0.1 g/cm3	沸点	630.5±55.0 °C at 760 mmHg
	分子式	C₂₈H₃₇ClO₇	熔点	210ºC
	MSDS	中文版美版	闪点	335.1±31.5 °C
	符号	GHS08	信号词	Danger

丙酸倍氯米松用途

Beclometasone二丙酸盐是糖皮质素激动剂,为beclometasone游离形式的原药。

中文名	丙酸倍氯米松
英文名	beclomethasone dipropionate
中文别名	丙酸倍氯米松 \| 倍氯米松丙酸酯 \| 倍氯米松二丙酸盐
英文别名	更多

描述	Beclometasone二丙酸盐是糖皮质素激动剂,为beclometasone游离形式的原药。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体研究领域 >> 炎症/免疫
参考文献	[1]. Young PG, Skinner SJ, Black PN. Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol. 1995 Jan 24;273(1-2):137-43. [2]. Nicolini G, Cremonesi G, Melani AS. Inhaled corticosteroid therapy with nebulized beclometasone dipropionate. Pulm Pharmacol Ther. 2010 Jun;23(3):145-55. [3]. Delacourt C, et al. Comparison of the efficacy and safety of nebulized beclometasone dipropionate and budesonide in severe persistent childhood asthma. Respir Med. 2003 Feb;97 Suppl B:S27-33.

描述

Beclometasone二丙酸盐是糖皮质素激动剂,为beclometasone游离形式的原药。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

研究领域 >> 炎症/免疫

参考文献

[1]. Young PG, Skinner SJ, Black PN. Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol. 1995 Jan 24;273(1-2):137-43.

[2]. Nicolini G, Cremonesi G, Melani AS. Inhaled corticosteroid therapy with nebulized beclometasone dipropionate. Pulm Pharmacol Ther. 2010 Jun;23(3):145-55.

[3]. Delacourt C, et al. Comparison of the efficacy and safety of nebulized beclometasone dipropionate and budesonide in severe persistent childhood asthma. Respir Med. 2003 Feb;97 Suppl B:S27-33.

密度	1.3±0.1 g/cm3
沸点	630.5±55.0 °C at 760 mmHg
熔点	210ºC
分子式	C₂₈H₃₇ClO₇
分子量	521.042
闪点	335.1±31.5 °C
精确质量	520.222778
PSA	106.97000
LogP	4.59
外观性状	白色结晶粉末
蒸汽压	0.0±4.2 mmHg at 25°C
折射率	1.564
储存条件	2-8℃ 避光，阴凉干燥处，密封保存 v
稳定性	常温常压下稳定，类白色或微黄色结晶性粉
分子结构	1、摩尔折射率：133.38 2、摩尔体积（m³/mol）：410.2 3、等张比容（90.2K）：1099.5 4、表面张力（dyne/cm）：51.5 5、极化率（10 ^-24cm ³）：52.87
计算化学	1、疏水参数计算参考值（XlogP）：3.1 2、氢键供体数量：2 3、氢键受体数量：6 4、可旋转化学键数量：6 5、互变异构体数量：8 6、拓扑分子极性表面积（TPSA）：83.6 7、重原子数量：26 8、表面电荷：0 9、复杂度：516 10、同位素原子数量：0 11、确定原子立构中心数量：0 12、不确定原子立构中心数量：1 13、确定化学键立构中心数量：0 14、不确定化学键立构中心数量：0 15、共价键单元数量：1
更多	1. 性状：未确定 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：未确定 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：未确定

丙酸倍氯米松MSDS英文版

丙酸倍氯米松生态学数据:

易燃; 燃烧产生有毒氯化物烟雾

丙酸倍氯米松毒性英文版

符号	GHS08
信号词	Danger
危害声明	H360
警示性声明	P201-P308 + P313
个人防护装备	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T:Toxic
风险声明 (欧洲)	R60;R61
安全声明 (欧洲)	S53-S36/37/39-S45
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	TU3805000
海关编码	2937290090

海关编码	2937290090

The use of hydrazine-based derivatization reagents for improved sensitivity and detection of carbonyl containing compounds using MALDI-MSI.

Anal. Bioanal. Chem 407(8) , 2085-94, (2015)

Hydrazine-based derivatization reagents have been used to detect the presence of the carbonyl containing glucocorticoid fluticasone proprionate in rat lung tissue by MALDI-MSI. Such reagents also act ...

[Beclomethasone dipropionate, budesonide and flunisolide in the treatment of bronchial asthma (a review of the literature and the authors' own research)].

Ter. Arkh. 67(3) , 34-8, (1995)

Inhalation corticosteroids (beclometasone dipropionate, budesonide, flunisolide) proved effective against bronchial asthma (BA) and safe as they induce no severe systemic side effects. Of these three ...

Air-jet and vibrating-mesh nebulization of niosomes generated using a particulate-based proniosome technology.

Int. J. Pharm. 444(1-2) , 193-9, (2013)

The aerosol properties of niosomes were studied using Aeroneb Pro and Omron MicroAir vibrating-mesh nebulizers and Pari LC Sprint air-jet nebulizer. Proniosomes were prepared by coating sucrose partic...

9-Chloro-16-β-methyl-11-β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-Dipropionate

Viarex

Beconasol

Becloval

(11b,16b)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione

(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(propanoyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate

Becodisks

pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-

Anceron

Vancenase AQ

propanoate de (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-triméthyl-3-oxo-17-[(propanoyloxy)acétyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yle

(11b,16b)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate

Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)-

(11β,16β)-9-Chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate

EINECS 226-886-0

Beclomethasone dipropionate (USP)

Beclomethasone dipropionate

Andion

MFCD00135613

(8S,9R,10S,11S,13S,14S,16S,17R)-9-Chlor-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(propanoyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylpropanoat

9-Chloro-11b-hydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-Dipropionate

Beclometasone dipropionate