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胸腺肽α1

更新时间:2024-01-02 20:41:44

胸腺肽α1结构式
胸腺肽α1结构式
品牌特惠专场
常用名 胸腺肽α1 英文名 Thymosin α1
CAS号 62304-98-7 分子量 3108.275
密度 1.4±0.1 g/cm3 沸点 2899.7±65.0 °C at 760 mmHg
分子式 C129H215N33O55 熔点 N/A
MSDS 美版 闪点 1707.5±34.3 °C

 胸腺肽α1用途


Thymalfasin (thymosin-alpha 1) 是一个免疫调节化合物,能够提高 Thl 的免疫应答。

 胸腺肽α1名称

中文名 胸腺28肽
英文名 Thymosin α1
中文别名 胸腺素Α1 | 胸腺素A-1 | 胸腺肽Α1 | 胸腺肽alpha1 | 胸腺 28肽 | 醋酸胸腺肽Alpha1 | 胸腺肽A-1 | 胸腺阿尔法一 | 胸腺肽 alpha 1 | 醋酸胸腺肽α1 | 胸腺法新
英文别名 更多

 胸腺肽α1生物活性

描述 Thymalfasin (thymosin-alpha 1) 是一个免疫调节化合物,能够提高 Thl 的免疫应答。
相关类别
体外研究 Thymalfasin已被证明在免疫功能障碍的多个实验模型中有效,主要是感染性疾病,如肝炎(土拨鼠)和流感(小鼠),以及癌症,如黑色素瘤(小鼠)和结肠直肠癌(大鼠),其中thymalfasin已显示抗肿瘤效果[2]。
体内研究 Thymalfasin已被证明在免疫功能障碍的多个实验模型中有效,主要是感染性疾病,如肝炎(土拨鼠)和流感(小鼠),以及癌症,如黑色素瘤(小鼠)和结肠直肠癌(大鼠),其中thymalfasin已显示抗肿瘤效果[2]。
参考文献

[1]. Lao X et al. A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects. Apoptosis. 2015 Oct;20(10):1307-20.

[2]. Sjogren MH et al. Thymalfasin: an immune system enhancer for the treatment of liver disease. J Gastroenterol Hepatol. 2004 Dec;19(12):S69-72.

 胸腺肽α1物理化学性质

密度 1.4±0.1 g/cm3
沸点 2899.7±65.0 °C at 760 mmHg
分子式 C129H215N33O55
分子量 3108.275
闪点 1707.5±34.3 °C
精确质量 3106.504150
PSA 1456.35000
LogP -9.87
外观性状 白色粉末
蒸汽压 0.0±0.6 mmHg at 25°C
折射率 1.563
储存条件 −20°C

 胸腺肽α1安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
WGK德国 3

 胸腺肽α1文献4

更多文献
Production of Nα-acetylated thymosin α1 in Escherichia coli.

Microb. Cell Fact. 10 , 26, (2011)

Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can o...

Thymosin alpha 1: biological activities, applications and genetic engineering production.

Peptides 31 , 2151-2158, (2010)

Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate...

Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice.

Front. Biosci. 17 , 3004-3013, (2011)

Tregs are involved in immune disorder during sepsis; they can lead to a Th2 immune reaction. Their inhibitory effects can help alleviate inflammatory injury, but may also cause secondary immune inhibi...

 胸腺肽α1英文别名

N-Acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-a 
lpha-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-asparagine
ZADAXIN
THYMOSIN ALPHA1 BOVINE
Thymosin alpha1
thymalfasin
AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Thymosin a1 Acetate
MFCD00076889
Thymosin Alpha1 Acetate
THYMOSIN A1
L-Asparagine, N-acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-
L-Asparagine, N-acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leuc 
yl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-
THYMOSIN A1 BOVINE
N-Acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-asparagine
Thymosin α1 Acetate
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