胸腺肽α1结构式
|
常用名 | 胸腺肽α1 | 英文名 | Thymosin α1 |
---|---|---|---|---|
CAS号 | 62304-98-7 | 分子量 | 3108.275 | |
密度 | 1.4±0.1 g/cm3 | 沸点 | 2899.7±65.0 °C at 760 mmHg | |
分子式 | C129H215N33O55 | 熔点 | N/A | |
MSDS | 美版 | 闪点 | 1707.5±34.3 °C |
胸腺肽α1用途Thymalfasin (thymosin-alpha 1) 是一个免疫调节化合物,能够提高 Thl 的免疫应答。 |
中文名 | 胸腺28肽 |
---|---|
英文名 | Thymosin α1 |
中文别名 | 胸腺素Α1 | 胸腺素A-1 | 胸腺肽Α1 | 胸腺肽alpha1 | 胸腺 28肽 | 醋酸胸腺肽Alpha1 | 胸腺肽A-1 | 胸腺阿尔法一 | 胸腺肽 alpha 1 | 醋酸胸腺肽α1 | 胸腺法新 |
英文别名 | 更多 |
描述 | Thymalfasin (thymosin-alpha 1) 是一个免疫调节化合物,能够提高 Thl 的免疫应答。 |
---|---|
相关类别 | |
体外研究 | Thymalfasin已被证明在免疫功能障碍的多个实验模型中有效,主要是感染性疾病,如肝炎(土拨鼠)和流感(小鼠),以及癌症,如黑色素瘤(小鼠)和结肠直肠癌(大鼠),其中thymalfasin已显示抗肿瘤效果[2]。 |
体内研究 | Thymalfasin已被证明在免疫功能障碍的多个实验模型中有效,主要是感染性疾病,如肝炎(土拨鼠)和流感(小鼠),以及癌症,如黑色素瘤(小鼠)和结肠直肠癌(大鼠),其中thymalfasin已显示抗肿瘤效果[2]。 |
参考文献 |
密度 | 1.4±0.1 g/cm3 |
---|---|
沸点 | 2899.7±65.0 °C at 760 mmHg |
分子式 | C129H215N33O55 |
分子量 | 3108.275 |
闪点 | 1707.5±34.3 °C |
精确质量 | 3106.504150 |
PSA | 1456.35000 |
LogP | -9.87 |
外观性状 | 白色粉末 |
蒸汽压 | 0.0±0.6 mmHg at 25°C |
折射率 | 1.563 |
储存条件 | −20°C |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
---|---|
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
Production of Nα-acetylated thymosin α1 in Escherichia coli.
Microb. Cell Fact. 10 , 26, (2011) Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can o... |
|
Thymosin alpha 1: biological activities, applications and genetic engineering production.
Peptides 31 , 2151-2158, (2010) Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate... |
|
Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice.
Front. Biosci. 17 , 3004-3013, (2011) Tregs are involved in immune disorder during sepsis; they can lead to a Th2 immune reaction. Their inhibitory effects can help alleviate inflammatory injury, but may also cause secondary immune inhibi... |
N-Acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-a 
lpha-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-asparagine |
ZADAXIN |
THYMOSIN ALPHA1 BOVINE |
Thymosin alpha1 |
thymalfasin |
AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN |
Thymosin a1 Acetate |
MFCD00076889 |
Thymosin Alpha1 Acetate |
THYMOSIN A1 |
L-Asparagine, N-acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl- |
L-Asparagine, N-acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leuc 
yl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl- |
THYMOSIN A1 BOVINE |
N-Acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-asparagine |
Thymosin α1 Acetate |