Thymosin α1

Modify Date: 2024-01-02 20:41:44

Thymosin α1 Structure
Thymosin α1 structure
 Common Name Thymosin α1
CAS Number 62304-98-7 Molecular Weight 3108.275
Density 1.4±0.1 g/cm3 Boiling Point 2899.7±65.0 °C at 760 mmHg
Molecular Formula C129H215N33O55 Melting Point N/A
MSDS USA Flash Point 1707.5±34.3 °C

 Use of Thymosin α1


Thymalfasin is an immunomodulating agent able to enhance the Thl immune response. Sequence: N-acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn.

 Names

Name Thymosin α1
Synonym More Synonyms

 Thymosin α1 Biological Activity

Description Thymalfasin is an immunomodulating agent able to enhance the Thl immune response. Sequence: N-acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn.
Related Catalog
In Vitro Thymalfasin has been shown to have efficacy in multiple experimental models of immune dysfunction, mainly, infectious diseases such as hepatitis (woodchuck) and influenza (mouse), and cancer such as melanoma (mouse) and colorectal carcinoma (rat) where thymalfasin has shown antitumor effects[2].
In Vivo Thymalfasin has been shown to have efficacy in multiple experimental models of immune dysfunction, mainly, infectious diseases such as hepatitis (woodchuck) and influenza (mouse), and cancer such as melanoma (mouse) and colorectal carcinoma (rat) where thymalfasin has shown antitumor effects[2].
References

[1]. Lao X et al. A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects. Apoptosis. 2015 Oct;20(10):1307-20.

[2]. Sjogren MH et al. Thymalfasin: an immune system enhancer for the treatment of liver disease. J Gastroenterol Hepatol. 2004 Dec;19(12):S69-72.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 2899.7±65.0 °C at 760 mmHg
Molecular Formula C129H215N33O55
Molecular Weight 3108.275
Flash Point 1707.5±34.3 °C
Exact Mass 3106.504150
PSA 1456.35000
LogP -9.87
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.563
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles4

More Articles
Production of Nα-acetylated thymosin α1 in Escherichia coli.

Microb. Cell Fact. 10 , 26, (2011)

Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can o...

Thymosin alpha 1: biological activities, applications and genetic engineering production.

Peptides 31 , 2151-2158, (2010)

Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate...

Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice.

Front. Biosci. 17 , 3004-3013, (2011)

Tregs are involved in immune disorder during sepsis; they can lead to a Th2 immune reaction. Their inhibitory effects can help alleviate inflammatory injury, but may also cause secondary immune inhibi...

 Synonyms

N-Acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-a 
lpha-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-asparagine
ZADAXIN
THYMOSIN ALPHA1 BOVINE
Thymosin alpha1
thymalfasin
AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Thymosin a1 Acetate
MFCD00076889
Thymosin Alpha1 Acetate
THYMOSIN A1
L-Asparagine, N-acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-
L-Asparagine, N-acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leuc 
yl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-
THYMOSIN A1 BOVINE
N-Acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L-threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-α-aspartyl-L-leucyl-L-lysyl-L-α-glutamyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-asparagine
Thymosin α1 Acetate
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Chemsrc provides Thymosin α1(CAS#:62304-98-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Thymosin α1 are included as well.>> amp version: Thymosin α1

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