CGP 12177 hydrochloride结构式
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常用名 | CGP 12177 hydrochloride | 英文名 | CGP 12177 hydrochloride |
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| CAS号 | 64208-32-8 | 分子量 | 315.80 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C14H22ClN3O3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
CGP 12177 hydrochloride用途CGP 12177 ((±)-CGP 12177) hydrochloride 是一种 β Adrenergic Receptor 配体。 CGP 12177 hydrochloride 是 β1- 和 β2-AR 的高亲和力拮抗剂。 CGP 12177 hydrochloride 还显示出以较低的亲和力与 β3-AR 相互作用,并对啮齿动物和人类 β3-AR 表现出部分激动剂活性。 CGP 12177 hydrochloride 对大鼠肺动脉中的 α1-AR 表现出部分激动剂特性。 |
| 英文名 | 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one,hydrochloride |
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| 描述 | CGP 12177 ((±)-CGP 12177) hydrochloride 是一种 β Adrenergic Receptor 配体。 CGP 12177 hydrochloride 是 β1- 和 β2-AR 的高亲和力拮抗剂。 CGP 12177 hydrochloride 还显示出以较低的亲和力与 β3-AR 相互作用,并对啮齿动物和人类 β3-AR 表现出部分激动剂活性。 CGP 12177 hydrochloride 对大鼠肺动脉中的 α1-AR 表现出部分激动剂特性。 |
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| 相关类别 | |
| 靶点 |
Beta-1 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic receptor α1-adrenergic receptor |
| 参考文献 |
| 分子式 | C14H22ClN3O3 |
|---|---|
| 分子量 | 315.80 |
| 精确质量 | 315.13500 |
| PSA | 90.14000 |
| LogP | 2.17690 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 危险品运输编码 | NONH for all modes of transport |
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ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta.
Br. J. Pharmacol. 142 , 781-787, (2004) 1. The alpha(1)-adrenoceptor antagonist properties of the beta-adrenoceptor nonconventional partial agonist, CGP 12177A, was investigated in functional assays in rat aorta and in radioligand binding a... |
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Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice.
Br. J. Pharmacol. 130 , 747-758, (2000) The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor antagonist... |
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The effects of beta-adrenoceptor agonists on KCl-induced rhythmic contraction in the ureter of guinea pig.
J. Smooth Muscle Res. 36 , 13-19, (2000) In the present study, we tried to determine what effects were induced by beta-adrenoceptor agonists on 40 mM KCl-induced rhythmic contraction and to clarify which beta-adrenoceptor subtypes are involv... |
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