CGP 12177 hydrochloride
CGP 12177 hydrochloride structure
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Common Name | CGP 12177 hydrochloride | ||
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| CAS Number | 64208-32-8 | Molecular Weight | 315.80 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H22ClN3O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of CGP 12177 hydrochlorideCGP 12177 ((±)-CGP 12177) hydrochloride is a β Adrenergic Receptor Ligand. CGP 12177 hydrochloride is a high affinity antagonist of β1- and β2-AR. CGP 12177 hydrochloride is also shown to interact, with a lower affinity, with the β3-AR and to exhibit a partial agonist activity on rodent and human β3-AR. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery[1]. |
| Name | 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one,hydrochloride |
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| Description | CGP 12177 ((±)-CGP 12177) hydrochloride is a β Adrenergic Receptor Ligand. CGP 12177 hydrochloride is a high affinity antagonist of β1- and β2-AR. CGP 12177 hydrochloride is also shown to interact, with a lower affinity, with the β3-AR and to exhibit a partial agonist activity on rodent and human β3-AR. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery[1]. |
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| Related Catalog | |
| Target |
Beta-1 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic receptor α1-adrenergic receptor |
| References |
| Molecular Formula | C14H22ClN3O3 |
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| Molecular Weight | 315.80 |
| Exact Mass | 315.13500 |
| PSA | 90.14000 |
| LogP | 2.17690 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta.
Br. J. Pharmacol. 142 , 781-787, (2004) 1. The alpha(1)-adrenoceptor antagonist properties of the beta-adrenoceptor nonconventional partial agonist, CGP 12177A, was investigated in functional assays in rat aorta and in radioligand binding a... |
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Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice.
Br. J. Pharmacol. 130 , 747-758, (2000) The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor antagonist... |
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The effects of beta-adrenoceptor agonists on KCl-induced rhythmic contraction in the ureter of guinea pig.
J. Smooth Muscle Res. 36 , 13-19, (2000) In the present study, we tried to determine what effects were induced by beta-adrenoceptor agonists on 40 mM KCl-induced rhythmic contraction and to clarify which beta-adrenoceptor subtypes are involv... |