123691-29-2

123691-29-2 structure

Name: CGP 36216
Chemical Name: (3-Aminopropyl)ethylphosphinic acid hydrochloride (1:1)
CAS Number: 123691-29-2
Molecular Formula: C₅H₁₄NO₂P
Molecular Weight: 151.14
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2017-06-09 15:31:53
Modify Date: 2022-05-20 20:36:49
CGP36216 (Compound 9) is a GABAB receptor antagonist. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 can be used for research of anxiety and trauma-related disorders[1][2].

Name	(3-Aminopropyl)ethylphosphinic acid hydrochloride (1:1)

Description	CGP36216 (Compound 9) is a GABAB receptor antagonist. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 can be used for research of anxiety and trauma-related disorders[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	GABAB receptor[1]
References	[1]. William Howson, et al. Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity. Bioorganic & Medicinal Chemistry Letters. Volume 3, Issue 4, April 1993, Pages 515-518. [2]. Adkins JM, et al. Presynaptic GABAB receptor inhibition sex dependently enhances fear extinction and attenuates fear renewal. Psychopharmacology (Berl). 2021 Aug;238(8):2059-2071.