Psora-4

更新时间：2024-01-12 14:45:16

Psora-4结构式	常用名	Psora-4	英文名	Psora-4
	CAS号	724709-68-6	分子量	334.36500
	密度	1.246g/cm3	沸点	537.7ºC at 760 mmHg
	分子式	C₂₁H₁₈O₄	熔点	N/A
	MSDS	中文版美版	闪点	279ºC
	符号	GHS07	信号词	Warning

Psora-4用途

Psora-4是一种有效的选择性Kv1抑制剂。3(电压门控钾通道),EC50为3 nM【1】。Psora-4具有免疫抑制活性,并在体外抑制人和大鼠髓鞘特异性效应记忆T细胞的增殖[2]。

英文名	4-(4-phenylbutoxy)furo[3,2-g]chromen-7-one
英文别名	更多

描述	Psora-4是一种有效的选择性Kv1抑制剂。3(电压门控钾通道),EC50为3 nM【1】。Psora-4具有免疫抑制活性,并在体外抑制人和大鼠髓鞘特异性效应记忆T细胞的增殖[2]。
相关类别	研究领域 >> 炎症/免疫信号通路 >> 跨膜转运 >> 钾通道
参考文献	[1]. Vennekamp J, et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun;65(6):1364-74.

密度	1.246g/cm3
沸点	537.7ºC at 760 mmHg
分子式	C₂₁H₁₈O₄
分子量	334.36500
闪点	279ºC
精确质量	334.12100
PSA	52.58000
LogP	4.94090
外观性状	固体
折射率	1.626
储存条件	2-8°C，密封，干燥，避光

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335-H413
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	C
危险品运输编码	NONH for all modes of transport

Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.

CNS Neurosci. Ther. 21 , 558-67, (2015)

The self-repair ability of neural progenitor cells (NPCs) has been found to be activated and protected in several therapies helpful in multiple sclerosis (MS), an inflammatory demyelinating disease of...

K+ channels as targets for specific immunomodulation.

Trends Pharmacol. Sci. 25 , 280-289, (2004)

The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The c...

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

Mol. Pharmacol. 65 , 1364-1374, (2004)

The lymphocyte potassium channel Kv1.3 is widely regarded as a promising new target for immunosuppression. To identify a potent small-molecule Kv1.3 blocker, we synthesized a series of 5-phenylalkoxyp...

Lopac-P-9872

5-(4-Phenylbutoxy)psoralen

Psora-4