Psora-4

Modify Date: 2024-01-12 14:45:16

Psora-4 Structure
Psora-4 structure
Common Name Psora-4
CAS Number 724709-68-6 Molecular Weight 334.36500
Density 1.246g/cm3 Boiling Point 537.7ºC at 760 mmHg
Molecular Formula C21H18O4 Melting Point N/A
MSDS Chinese USA Flash Point 279ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Psora-4


Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2].

 Names

Name 4-(4-phenylbutoxy)furo[3,2-g]chromen-7-one
Synonym More Synonyms

 Psora-4 Biological Activity

Description Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2].
Related Catalog
References

[1]. Vennekamp J, et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun;65(6):1364-74.

 Chemical & Physical Properties

Density 1.246g/cm3
Boiling Point 537.7ºC at 760 mmHg
Molecular Formula C21H18O4
Molecular Weight 334.36500
Flash Point 279ºC
Exact Mass 334.12100
PSA 52.58000
LogP 4.94090
Index of Refraction 1.626

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335-H413
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes C
RIDADR NONH for all modes of transport

 Articles3

More Articles
Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.

CNS Neurosci. Ther. 21 , 558-67, (2015)

The self-repair ability of neural progenitor cells (NPCs) has been found to be activated and protected in several therapies helpful in multiple sclerosis (MS), an inflammatory demyelinating disease of...

K+ channels as targets for specific immunomodulation.

Trends Pharmacol. Sci. 25 , 280-289, (2004)

The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The c...

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

Mol. Pharmacol. 65 , 1364-1374, (2004)

The lymphocyte potassium channel Kv1.3 is widely regarded as a promising new target for immunosuppression. To identify a potent small-molecule Kv1.3 blocker, we synthesized a series of 5-phenylalkoxyp...

 Synonyms

Lopac-P-9872
5-(4-Phenylbutoxy)psoralen
Psora-4
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