Psora-4

Modify Date: 2024-01-12 14:45:16

Psora-4 structure	Common Name	Psora-4
	CAS Number	724709-68-6	Molecular Weight	334.36500
	Density	1.246g/cm3	Boiling Point	537.7ºC at 760 mmHg
	Molecular Formula	C₂₁H₁₈O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	279ºC
	Symbol	GHS07	Signal Word	Warning

Use of Psora-4

Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2].

Name	4-(4-phenylbutoxy)furo[3,2-g]chromen-7-one
Synonym	More Synonyms

Description	Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Vennekamp J, et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun;65(6):1364-74.

Density	1.246g/cm3
Boiling Point	537.7ºC at 760 mmHg
Molecular Formula	C₂₁H₁₈O₄
Molecular Weight	334.36500
Flash Point	279ºC
Exact Mass	334.12100
PSA	52.58000
LogP	4.94090
Index of Refraction	1.626

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335-H413
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	C
RIDADR	NONH for all modes of transport

Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.

CNS Neurosci. Ther. 21 , 558-67, (2015)

The self-repair ability of neural progenitor cells (NPCs) has been found to be activated and protected in several therapies helpful in multiple sclerosis (MS), an inflammatory demyelinating disease of...

K+ channels as targets for specific immunomodulation.

Trends Pharmacol. Sci. 25 , 280-289, (2004)

The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The c...

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

Mol. Pharmacol. 65 , 1364-1374, (2004)

The lymphocyte potassium channel Kv1.3 is widely regarded as a promising new target for immunosuppression. To identify a potent small-molecule Kv1.3 blocker, we synthesized a series of 5-phenylalkoxyp...

Lopac-P-9872

5-(4-Phenylbutoxy)psoralen

Psora-4