雷莫拉宁

更新时间：2024-01-04 13:16:01

雷莫拉宁结构式	常用名	雷莫拉宁	英文名	ramoplanin A2
	CAS号	76168-82-6	分子量	2554.066
	密度	1.5±0.1 g/cm3	沸点	N/A
	分子式	C₁₀₆H₁₇₀ClN₂₁O₃₀	熔点	>218 °C(dec.)
	MSDS	中文版美版	闪点	N/A
	符号	GHS05	信号词	Danger

雷莫拉宁用途

Ramoplanin 是一种源于 Actinoplanes spp 的糖肽类抗生素,具有抗革兰氏阳性菌活性。

中文名	雷莫拉宁
英文名	Ramoplanin
英文别名	更多

描述	Ramoplanin 是一种源于 Actinoplanes spp 的糖肽类抗生素,具有抗革兰氏阳性菌活性。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
靶点	Bacteria[1]
体外研究	雷莫普兰通过脂质II阻断肽聚糖合成,对革兰氏阳性需氧菌和厌氧菌发挥杀菌作用[1]。
体内研究	雷莫普兰(100,500μg/ml；p.o.；8天)在治疗期间将万古霉素耐药肠球菌(VRE)抑制到无法检测的水平[1]。动物模型：雌性CF1小鼠(25-30g)[1]剂量：100μg/ml,500μg/ml,口服；连续8天结果：治疗过程中出现大便VRE不可检测水平。
参考文献	[1]. Stiefel U, et al. Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice. Antimicrob Agents Chemother. 2004 Jun;48(6):2144-8. [2]. Cheng M, et al. Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus. Antimicrob Agents Chemother. 2014 Nov;58(11):6819-27.

密度	1.5±0.1 g/cm3
熔点	>218 °C(dec.)
分子式	C₁₀₆H₁₇₀ClN₂₁O₃₀
分子量	2554.066
精确质量	2552.035156
LogP	-6.39
外观性状	固体
折射率	1.689
储存条件	-20°C

符号	GHS05
信号词	Danger
危害声明	H318
警示性声明	P280-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	C
危险品运输编码	NONH for all modes of transport
RTECS号	VE5050000

Functional identification of the gene encoding the enzyme involved in mannosylation in ramoplanin biosynthesis in Actinoplanes sp.

Biotechnol. Lett. 35(9) , 1501-8, (2013)

Ramoplanin is a lipopeptide antibiotic active against multi-drug-resistant, Gram-positive pathogens. Structurally, it contains a di-mannose moiety attached to the peptide core at Hpg(11). The biosynth...

Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics.

J. Am. Chem. Soc. 126(24) , 7462-3, (2004)

Ramoplanin is a potent cyclic lipoglycodepsipeptide antibiotic that disrupts bacterial cell wall synthesis by binding to the peptidoglycan intermediate Lipid II and blocking its polymerization to form...

Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity.

J. Am. Chem. Soc. 126(4) , 1041-3, (2004)

The total synthesis and evaluation of three key ramoplanin aglycon analogues are detailed. The first (5a) represents replacement of the labile depsipeptide ester with a stable amide (HAsn2 --> Dap2) w...

A 16686A

N-[(3S,6R,9S,15S,18R,21S,24R,27S,30S,33R,36S,39R,42R,45R,48S,49S)-24,42-Bis(3-aminopropyl)-27-benzyl-49-carbamoyl-3-(3-chloro-4-hydroxyphenyl)-18,39-bis[(1R)-1-hydroxyethyl]-30-[(1S)-1-hydroxyethyl ]-15,33,36,45-tetrakis(4-hydroxyphenyl)-9-isobutyl-21-(4-{[2-O-(α-D-mannopyranosyl)-α-D-mannopyranosyl]oxy}phenyl)-6-methyl-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-hexadecaoxo-1-oxa-4,7,1 0,13,16,19,22,25,28,31,34,37,40,43,46-pentad

L-Aspartamide, N-[(3S,6R,9S,15S,18R,21S,24R,27S,30S,33R,36S,39R,42R,45R,48S,49S)-49-(aminocarbonyl)-24,42-bis(3-aminopropyl)-3-(3-chloro-4-hydroxyphenyl)-18,39-bis[(1R)-1-hydroxyethyl]-30-[(1S)-1-h ;ydroxyethyl]-15,33,36,45-tetrakis(4-hydroxyphenyl)-21-[4-[(2-O-α-D-mannopyranosyl-α-D-mannopyranosyl)oxy]phenyl]-6-methyl-9-(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-hexade caoxo-27-(phenylmethyl)-1-oxa-4,7,10,13,16,1

ramoplanin A2

A 16686

Antibiotic A 16686