10-去乙酰紫杉醇结构式
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常用名 | 10-去乙酰紫杉醇 | 英文名 | Deacetyltaxol |
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CAS号 | 78432-77-6 | 分子量 | 811.870 | |
密度 | 1.4±0.1 g/cm3 | 沸点 | 959.5±65.0 °C at 760 mmHg | |
分子式 | C45H49NO13 | 熔点 | 182-184ºC | |
MSDS | N/A | 闪点 | 534.1±34.3 °C |
10-去乙酰紫杉醇用途10-Deacetyltaxol (10-Deacetylpaclitaxel) 是从红豆杉中分离得到的一种紫杉醇衍生物。10-Deacetyltaxol (10-Deacetylpaclitaxel) 能促进微管蛋白的聚合,在体外抑制由冷或钙离子诱导的微管解聚。10-Deacetyltaxol (10-Deacetylpaclitaxel) 对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。 |
中文名 | 7-表-10-脱乙酰基紫杉醇 |
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英文名 | Deacetyltaxol |
中文别名 | 7-表-去乙酰基紫杉醇 | 10-去乙酰基紫杉醇 | 10-去乙酰紫杉醇 | 10-脱乙酰基紫杉醇 | 10-去乙酰-7-差向紫杉醇 | 7-表-10-去乙酰基紫杉 | 7-表-10-去乙酰基紫杉醇 | 7-表-10-去乙酰基紫杉醇 |
英文别名 | 更多 |
描述 | 10-Deacetyltaxol (10-Deacetylpaclitaxel) 是从红豆杉中分离得到的一种紫杉醇衍生物。10-Deacetyltaxol (10-Deacetylpaclitaxel) 能促进微管蛋白的聚合,在体外抑制由冷或钙离子诱导的微管解聚。10-Deacetyltaxol (10-Deacetylpaclitaxel) 对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。 |
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相关类别 | |
靶点 |
tubulin[2] |
参考文献 |
[2]. Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A. |
密度 | 1.4±0.1 g/cm3 |
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沸点 | 959.5±65.0 °C at 760 mmHg |
熔点 | 182-184ºC |
分子式 | C45H49NO13 |
分子量 | 811.870 |
闪点 | 534.1±34.3 °C |
精确质量 | 811.320374 |
PSA | 215.22000 |
LogP | 6.74 |
蒸汽压 | 0.0±0.3 mmHg at 25°C |
折射率 | 1.652 |
储存条件 | -20°C Freezer |
安全声明 (欧洲) | 24/25 |
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海关编码 | 29329990 |
~89% 10-去乙酰紫杉醇 78432-77-6 |
文献:Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190 |
~% 10-去乙酰紫杉醇 78432-77-6 |
文献:Tetrahedron, , vol. 45, # 13 p. 4177 - 4190 |
~% 10-去乙酰紫杉醇 78432-77-6 |
文献:Tetrahedron, , vol. 45, # 13 p. 4177 - 4190 |
~9% 10-去乙酰紫杉醇 78432-77-6
详细
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文献:Chemistry Letters, , vol. 37, # 3 p. 362 - 363 |
~98% 10-去乙酰紫杉醇 78432-77-6 |
文献:Hauser, Inc. Patent: US5629433 A1, 1997 ; |
~95% 10-去乙酰紫杉醇 78432-77-6 |
文献:Zheng, Qun Y.; Darbie, Lynn G.; Cheng, Xiaoqin; Murray, Christopher K. Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2001 - 2004 |
~5% 10-去乙酰紫杉醇 78432-77-6 |
文献:Chemistry Letters, , vol. 37, # 3 p. 362 - 363 |
~% 10-去乙酰紫杉醇 78432-77-6 |
文献:Tetrahedron, , vol. 45, # 13 p. 4177 - 4190 |
benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |
7-epi-10-deacetyltaxol |
b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester |
(2α,5β,7β,10β,13α)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
7-EPI-10-DEACETYL PACLITAXEL |
10-DEACETYLTAXOL |
10-Desacetyl Paclitaxel |
(2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
10-Desacetyltaxol |
Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,1 3-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |
10-Deacetylpaclitaxel |
10-DAT |