甲磺酸达比加群酯

• 常用名: 甲磺酸达比加群酯
• 英文名: Dabigatran etexilate mesylate
• CAS号: 872728-81-9
• 分子量: 723.839
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₅H₄₅N₇O₈S
• 熔点: N/A
• 闪点: N/A

甲磺酸达比加群酯用途

Dabigatran etexilate mesylate (BIBR 1048MS)是口服活性的dabigatran前药。Dabigatran是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。

甲磺酸达比加群酯名称

• 中文名: 甲磺酸达比加群酯
• 英文名: dabigatran etexilate methanesulfonate
• 中文别名: 达比加群酯 | 达比加群酯甲磺酸盐

甲磺酸达比加群酯生物活性

• 描述: Dabigatran etexilate mesylate (BIBR 1048MS)是口服活性的dabigatran前药。Dabigatran是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 凝血酶
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62.

  [2]. Kansal AR, Sorensen SV, Gani R, Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients withatrial fibrillation. Heart. 2012 Apr;98(7):573-8.

甲磺酸达比加群酯物理化学性质

• 分子式: C₃₅H₄₅N₇O₈S
• 分子量: 723.839
• 精确质量: 723.305054
• PSA: 216.78000
• LogP: 6.96070
• 储存条件: 2-8°C

甲磺酸达比加群酯英文别名

• N-[[2-[[[4-[[[(HEXYLOXY)CARBONYL]AMINO]IMINOMETHYL]PHENYL]AMINO]METHYL]-1-METHYL-1H-BENZIMIDAZOL-5-Y
• β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate (1:1)
• Pradaxa
• BIBR-1048 (DABIGATRAN)METHANESULFONATE
• Ethyl N-[(2-{[(4-{N-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-2-pyridinyl-β-alaninate methanesulfonate (1:1)
• Dabigatran etexilate mesilate impurity
• Dabigatran etexilate (mesylate)
• Dabigatran etexilate
• PRODUCTS Dabigatran etexilate mesylate
• Dabigatran Etexilate Mesylate
• dabigatran etexilate methanesulfonate
• Pradaxa mesylate