![]() Quinelorane dihydrochloride结构式
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常用名 | Quinelorane dihydrochloride | 英文名 | Quinelorane hydrochloride |
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CAS号 | 97548-97-5 | 分子量 | 319.27300 | |
密度 | N/A | 沸点 | 438.5ºC at 760 mmHg | |
分子式 | C14H24Cl2N4 | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | 219ºC |
Quinelorane dihydrochloride用途盐酸奎尼洛兰(LY163502)是一种有效的多巴胺D3/D2受体激动剂。奎尼洛兰具有神经和精神疾病研究的潜力[1][2]。 |
英文名 | (5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine,dihydrochloride |
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英文别名 | 更多 |
描述 | 盐酸奎尼洛兰(LY163502)是一种有效的多巴胺D3/D2受体激动剂。奎尼洛兰具有神经和精神疾病研究的潜力[1][2]。 |
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相关类别 | |
靶点 |
D2 Receptor D3 Receptor |
体内研究 | 盐酸喹诺醚(LY163502;0.003,0.01 mg/kg;s.c.)可减少GABA外流,对雄性Wistar大鼠(300 g)有显著影响,为0.01 mg/kg,而非0.003 mg/kg[1]。盐酸奎尼洛兰(0.032,0.32,3.2,5.6 mg/kg;IP)显著且剂量依赖性地增加Sprague-Dawley大鼠的运动活性。没有性别和性别互动的主要影响[1]。盐酸喹诺醚显著降低雄性和雌性近交FVB/NJ、BALB/cJ、BALB/cByJ、C57BL/6J、Swiss Webster、A/J、DBA/2J、129S1/SvImJ和129S6/SvEvTac小鼠的活性[1]。 |
参考文献 |
沸点 | 438.5ºC at 760 mmHg |
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分子式 | C14H24Cl2N4 |
分子量 | 319.27300 |
闪点 | 219ºC |
精确质量 | 318.13800 |
PSA | 55.04000 |
LogP | 3.77110 |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
Effects of the selective dopaminergic D2 agonist quinelorane on the activity of dopaminergic and noradrenergic neurons projecting to the diencephalon of the rat.
J. Pharmacol. Exp. Ther. 268 , 645, (1994) The purpose of the present study was to characterize dopaminergic D2 receptor-mediated regulation of catecholaminergic neurons in the diencephalon by examining the acute effects of the potent and sele... |
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Effects of LY163502, a D2 dopaminergic agonist, on the sexual behavior of male rats.
Pharmacol. Biochem. Behav. 43 , 1087, (1992) LY163502, a selective D2 receptor agonist, has been reported to stimulate sexual behavior in both copulating and noncopulating male rats. Three experiments were conducted to further characterize the r... |
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Oscillation of interspike interval length in substantia nigra dopamine neurons: effects of nicotine and the dopaminergic D2 agonist LY 163502 on electrophysiological activity.
Synapse 11 , 229, (1992) The rates and patterns of discharge activity exhibited by 16 spontaneously active substantia nigra pars compacta dopamine neurons were studied in halothane-anesthetized rats using three types of quant... |
Quinelorane HCl |
Quinelorane dihydrochloride |
LY-163,502 |
Quinerlorane hydrochloride |