CDK4/6-IN-16

Modify Date: 2024-02-05 23:05:58

CDK4/6-IN-16 structure	Common Name	CDK4/6-IN-16
	CAS Number	1169694-98-7	Molecular Weight	504.602
	Density	1.5±0.1 g/cm3	Boiling Point	729.5±70.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₃₃FN₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	395.0±35.7 °C

Use of CDK4/6-IN-16

CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer[1].

Name	2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol
Synonym	More Synonyms

Description	CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4:13 nM (IC50) CDK6
References	[1]. Richard V. Connors, et al. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors. WO2009085185A1.

Density	1.5±0.1 g/cm3
Boiling Point	729.5±70.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₃FN₈O
Molecular Weight	504.602
Flash Point	395.0±35.7 °C
Exact Mass	504.276123
LogP	1.86
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.735

Ethanol, 2-[[[1-[6-[(9-cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-4-piperidinyl]methyl]amino]-

2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol

CDK4/6-IN-16

Use of CDK4/6-IN-16

Names

CDK4/6-IN-16 Biological Activity

Chemical & Physical Properties

Synonyms