Lacidipine-d10

Modify Date: 2024-02-24 18:48:10

Lacidipine-d10 structure	Common Name	Lacidipine-d10
	CAS Number	1185245-62-8	Molecular Weight	465.60500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₃D₁₀NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lacidipine-d10

Lacidipine-d10 is the deuterium labeled Lacidipine. Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker[1][2].

Name	bis(1,1,2,2,2-pentadeuterioethyl) 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
Synonym	More Synonyms

Description	Lacidipine-d10 is the deuterium labeled Lacidipine. Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9. [3]. van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7. [4]. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7.

Molecular Formula	C₂₆H₂₃D₁₀NO₆
Molecular Weight	465.60500
Exact Mass	465.29400
PSA	90.93000
LogP	4.73130

GX-1048-d10

Lacipil-d10

Lacidipine-d10

Motens-d10

Caldine-d10

Lacirex-d10