Ivacaftor-d18 structure
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Common Name | Ivacaftor-d18 | ||
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CAS Number | 1413431-05-6 | Molecular Weight | 410.60200 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H10D18N2O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Ivacaftor-d18Ivacaftor-d18 is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2]. |
Name | Ivacaftor-d18 |
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Description | Ivacaftor-d18 is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2]. |
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Related Catalog | |
In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
References |
Molecular Formula | C24H10D18N2O3 |
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Molecular Weight | 410.60200 |
Exact Mass | 410.32300 |
PSA | 82.19000 |
LogP | 5.15400 |