Ac-Leu-Leu-Norleucinol
Modify Date: 2024-09-10 13:06:09
Ac-Leu-Leu-Norleucinol structure
|
Common Name | Ac-Leu-Leu-Norleucinol | ||
|---|---|---|---|---|
| CAS Number | 148333-42-0 | Molecular Weight | 399.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H37N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ac-Leu-Leu-NorleucinolAc-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1]. |
| Name | Ac-Leu-Leu-Norleucinol |
|---|
| Description | Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1]. |
|---|---|
| Related Catalog | |
| Target |
Calpain[1] |
| In Vivo | Ac-Leu-Leu-Norleucinol (10 mg/kg, 20 mg/kg; i.p.; single dose) effectively prevents Acetaminophen (HY-66005)-induced acute liver injury in mice model[1]. Animal Model: Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1] Dosage: 10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.) Administration: Intraperitoneal injection; collected tissue samples 24 hr after Result: Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST). Injection alone did not cause pathological changes in the liver. |
| References |
| Molecular Formula | C20H37N3O5 |
|---|---|
| Molecular Weight | 399.52 |