KRAS inhibitor-15 structure
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Common Name | KRAS inhibitor-15 | ||
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CAS Number | 2230873-75-1 | Molecular Weight | 451.34 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C20H17Cl2FN4OS | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of KRAS inhibitor-15KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
Name | KRAS inhibitor-15 |
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Description | KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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Related Catalog | |
Target |
KRas G12C:0.954 μM (IC50) |
References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
Molecular Formula | C20H17Cl2FN4OS |
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Molecular Weight | 451.34 |