2411786-32-6

2411786-32-6 structure

2411786-32-6 structure

Name: KRAS inhibitor-20
Chemical Name: KRAS inhibitor-20
CAS Number: 2411786-32-6
Molecular Formula: C₃₁H₄₀F₄N₆O₂
Molecular Weight: 604.68
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2022-10-22 21:40:39
Modify Date: 2024-04-03 11:29:52
KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM[1].

Name	KRAS inhibitor-20

Description	KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12C):<10 nM (IC50, [1])
In Vitro	KRAS inhibitor-20 (compound 12b) results KRasG12C alkylation human lung cancer adenocarcinoma (HCC 1171) with an EC50 value of 3.3 nM[1].
References	[1]. Kargbo RB. Small-Molecule Inhibitor of the Oncogenic KRASG12C Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13(5):767-769.

Molecular Formula	C₃₁H₄₀F₄N₆O₂
Molecular Weight	604.68