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300809-71-6

300809-71-6 structure
300809-71-6 structure
  • Name: KRAS inhibitor-9
  • Chemical Name: 4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline
  • CAS Number: 300809-71-6
  • Molecular Formula: C13H9ClN2S2
  • Molecular Weight: 292.807
  • Create Date: 2021-01-09 19:44:58
  • Modify Date: 2024-01-02 17:37:07
  • KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells.

Name 4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline
Synonyms 4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline
Benzenamine, 4-(2-benzothiazolylthio)-3-chloro-
MFCD00227023
4-(Benzothiazol-2-ylsulfanyl)-3-chloro-phenylamine
Density 1.5±0.1 g/cm3
Boiling Point 492.4±55.0 °C at 760 mmHg
Molecular Formula C13H9ClN2S2
Molecular Weight 292.807
Flash Point 251.6±31.5 °C
Exact Mass 291.989563
LogP 4.85
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.772
Hazard Codes Xi