Name | KRAS inhibitor-12 |
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Description | KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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Related Catalog | |
Target |
KRas G12C:0.537 μM (IC50) |
References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
Molecular Formula | C19H16Cl2FN5OS |
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Molecular Weight | 452.33 |