2230874-00-5

2230874-00-5 structure
2230874-00-5 structure
  • Name: KRAS inhibitor-12
  • Chemical Name: KRAS inhibitor-12
  • CAS Number: 2230874-00-5
  • Molecular Formula: C19H16Cl2FN5OS
  • Molecular Weight: 452.33
  • Catalog: Signaling Pathways GPCR/G Protein Ras
  • Create Date: 2022-07-01 22:17:24
  • Modify Date: 2024-01-13 17:50:53
  • KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

Name KRAS inhibitor-12
Description KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Related Catalog
Target

KRas G12C:0.537 μM (IC50)

References

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Molecular Formula C19H16Cl2FN5OS
Molecular Weight 452.33