As-358 hydrochloride

Modify Date: 2024-01-09 14:25:41

As-358 hydrochloride structure	Common Name	As-358 hydrochloride
	CAS Number	2374723-26-7	Molecular Weight	329.91
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₃₂ClNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of As-358 hydrochloride

As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].

Name	As-358 hydrochloride

Description	As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Filovirus
Target	IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)[1]
In Vitro	As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV)[1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.
In Vivo	As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1]. Animal Model: ICR mice[1] Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg Administration: IG; single (observed for 7 days) Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
References	[1]. Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726.

Molecular Formula	C₁₈H₃₂ClNO₂
Molecular Weight	329.91