PI3Kα-IN-7

Modify Date: 2024-04-08 00:01:26

PI3Kα-IN-7 Structure
PI3Kα-IN-7 structure
Common Name PI3Kα-IN-7
CAS Number 2417098-53-2 Molecular Weight 402.47
Density N/A Boiling Point N/A
Molecular Formula C17H22N8O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PI3Kα-IN-7


PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor. PI3Kα-IN-7 also inhibits PI3Kβ. PI3Kα-IN-7 decreases cancer cells mitochondrial membrane potential and induces apoptosis[1].

 Names

Name PI3Kα-IN-7

 PI3Kα-IN-7 Biological Activity

Description PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor. PI3Kα-IN-7 also inhibits PI3Kβ. PI3Kα-IN-7 decreases cancer cells mitochondrial membrane potential and induces apoptosis[1].
Related Catalog
Target

PI3Kα

PI3Kβ

In Vitro PI3Kα-IN-7 (Compound A12) shows potent antitumor activities against HCT116, PC-3, MCF-7, A549 and MDA-MB-231 cell lines with IC50 values of 3.24 μM, 14.37 μM, 7.39 μM, 7.10 μM, and 16.85 μM, respectively[1].
References

[1]. Ye T, et al. Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives as potent antitumor agents. Bioorg Chem. 2020 Jun;99:103796.

 Chemical & Physical Properties

Molecular Formula C17H22N8O2S
Molecular Weight 402.47