PI3Kα-IN-4h
Modify Date: 2024-04-02 21:04:47
PI3Kα-IN-4h structure
|
Common Name | PI3Kα-IN-4h | ||
|---|---|---|---|---|
| CAS Number | 2100855-80-7 | Molecular Weight | 483.532 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H25N7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3Kα-IN-4hPI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties. |
| Name | PI3Kα-IN-4h |
|---|
| Description | PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties. |
|---|---|
| References | References 1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122. View Related Products by Target PI3K |
| Molecular Formula | C26H25N7O3 |
|---|---|
| Molecular Weight | 483.532 |