pyridine-3-carboxamide,hydrochloride
Modify Date: 2024-01-05 17:09:43
pyridine-3-carboxamide,hydrochloride structure
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Common Name | pyridine-3-carboxamide,hydrochloride | ||
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| CAS Number | 25334-23-0 | Molecular Weight | 158.58600 | |
| Density | N/A | Boiling Point | 334.4ºC at 760mmHg | |
| Molecular Formula | C6H7ClN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 156ºC | |
Use of pyridine-3-carboxamide,hydrochlorideNicotinamide Hydrochloride is a form of vitamin B3 or niacin that inhibits sirtuin 2 (SIRT2) activity in vitro, with an EC50 of 2 μM. Nicotinamide Hydrochloride inhibits up to 90% melanoma cell number and increases cellular NAD+, ATP, ROS levels. Nicotinamide Hydrochloride inhibts tumor growth in vivo and improves survival of melanoma-bearing mice, which can be used for the research of skin cancers such as melanoma[1]. |
| Name | pyridine-3-carboxamide,hydrochloride |
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| Synonym | More Synonyms |
| Description | Nicotinamide Hydrochloride is a form of vitamin B3 or niacin that inhibits sirtuin 2 (SIRT2) activity in vitro, with an EC50 of 2 μM. Nicotinamide Hydrochloride inhibits up to 90% melanoma cell number and increases cellular NAD+, ATP, ROS levels. Nicotinamide Hydrochloride inhibts tumor growth in vivo and improves survival of melanoma-bearing mice, which can be used for the research of skin cancers such as melanoma[1]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite SIRT2:2 μM (EC50) |
| In Vitro | Nicotinamide Hydrochloride (0-50 mM, 24/48 h ) reduces cell number in a time-dependent and dose-dependent manner in A375 and SK-MEL-28 cells[1]. Nicotinamide Hydrochloride (10-50 mM, 24 h ) makes A375 cells undergo accumulation in G1 phase, reduction in S phase, and increase inthe sub-G1 (apoptosis) phase[1]. Nicotinamide Hydrochloride (1-50 mM, 6 h ) increases NAD+, ATP and ROS levels in A375 and SK-MEL-28 cells[1]. Nicotinamide Hydrochloride (0.01-20 mM, 1 h) inhibits purified SIRT2 enzymatic activity in vitro with an EC50 of 2 μM[1]. Cell Viability Assay[1] Cell Line: A375, SK-MEL-28, mouse B16-F10 cell Concentration: 0, 1, 20, 50 mM Incubation Time: 24 h, 48 h Result: Reduced cell number in a dose-dependent manner with a strong inhibitory effect at 20mM and an almost complete effect at 50 mM. Cell Cycle Analysis[1] Cell Line: A375, SK-MEL-28 Concentration: 10, 20, 50 mM Incubation Time: 24 h Result: Arrested A375 cells in G1 phase. |
| In Vivo | Nicotinamide Hydrochloride (Intraperitoneal injection, 1500 and 1800 mg/Kg, 5 days per week) inhibits tumor growth in murine metastatic melanoma model[1]. Nicotinamide Hydrochloride (Intraperitoneal injection, 1800 mg/Kg, once a day, murine metastatic melanoma model) affects IFN-γ (a key mediator of cell-mediated anti-tumor immunity), increases the plasma levels of eotaxin and IL-5, reduces the plasma levels of IL-3, IL-12, RANTES and IL-10[1]. Animal Model: C57BL/6 mice (subcutaneous injected with B16-F10 cells)[1] Dosage: 1000, 1500, 1800 mg/Kg. Administration: Intraperitoneal injection, 5 days per week (followed by 2-day rest) or once a day. Result: Inhibited tumor growth at 1500 and 1800 mg/Kg, and had no effect on the body weight. Increased the frequency of IFN-γ producing cells and modulated the protein levels of cytokines and chemokines in the plasma of tumor-bearing mice. |
| References |
| Boiling Point | 334.4ºC at 760mmHg |
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| Molecular Formula | C6H7ClN2O |
| Molecular Weight | 158.58600 |
| Flash Point | 156ºC |
| Exact Mass | 158.02500 |
| PSA | 55.98000 |
| LogP | 1.68280 |
| Vapour Pressure | 0.000128mmHg at 25°C |
| HS Code | 2933399090 |
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| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| pyridine-3-carboxamide hydrochloride |
| nicotinic acid amide,hydrochloride |
| NIACINAMIDE HYDROCHLORIDE |
| Nicotinsaeure-amid,Hydrochlorid |
| Nicotinamide hydrochloride |
| nicotinamide monohydrochloride |
| Nicotinamide HCl |
| 3-carbamoylpyridinium chloride |