Synstab A

Modify Date: 2024-01-16 17:02:19

Synstab A Structure
Synstab A structure
Common Name Synstab A
CAS Number 257612-36-5 Molecular Weight 501.61
Density 1.73g/cm3 Boiling Point N/A
Molecular Formula C15H13BrCl3N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Synstab A


Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells[1][2].

 Names

Name 4-bromo-N-[2,2,2-trichloro-1-(4-sulfamoylanilino)ethyl]benzamide

 Synstab A Biological Activity

Description Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells[1][2].
Related Catalog
Target

α-Tubulin and β-Tubulin interaction[1]

References

[1]. Gerry CJ, et al. Unifying principles of bifunctional, proximity-inducing small molecules. Nat Chem Biol. 2020 Apr;16(4):369-378.  

[2]. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300.  

 Chemical & Physical Properties

Density 1.73g/cm3
Molecular Formula C15H13BrCl3N3O3S
Molecular Weight 501.61
Exact Mass 498.89300
PSA 109.67000
LogP 5.87970
Index of Refraction 1.663
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