CDK9-IN-14

Modify Date: 2024-01-14 12:53:43

CDK9-IN-14 structure	Common Name	CDK9-IN-14
	CAS Number	2650640-17-6	Molecular Weight	419.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₃F₂N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK9-IN-14

CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1].

Name	CDK9-IN-14

Description	CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK9:6.92 nM (IC50)
In Vitro	CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM[1].
In Vivo	CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%[1]. Animal Model: Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)[1] Dosage: 5 mg/kg Administration: p.o., qd, for 9 days Result: Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.
References	[1]. WANG Zhenyu. Compound as cyclin-dependent kinase 9 inhibitor and use thereof. WO2021115335A1

Molecular Formula	C₂₁H₂₃F₂N₃O₄
Molecular Weight	419.42

CDK9-IN-14

Use of CDK9-IN-14

Names

CDK9-IN-14 Biological Activity

Chemical & Physical Properties