Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

Shugeng Cao, Brian T Murphy, Caleb Foster, John S Lazo, David G I Kingston, Shugeng Cao, Brian T. Murphy, Caleb Foster, John S. Lazo, David G.I. Kingston

Index: Bioorg. Med. Chem. 17 , 2276-81, (2009)

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Abstract

Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular are enzymes overexpressed in human cancer cells, and they represent potential molecular targets for novel cancer chemotherapeutic treatments. A number of analogs exhibited significant inhibitory activity against these enzymes, and the bioassay data in addition to structure-activity relationships of these compounds will be discussed.