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CP-67015

Names

[ CAS No. ]:
100325-51-7

[ Name ]:
CP-67015

[Synonym ]:
3-Quinolinecarboxylic acid,1,4-dihydro-6,8-difluoro-1-ethyl-4-oxo-7-(4-pyridinyl)
3-Quinolinecarboxylicacid,1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(4-pyridinyl)
CP-67,015

Biological Activity

[Description]:

CP-67015, a nalidixic acid analog, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Infection

[Target]

Topoisomerase II


[In Vitro]

CP-67015 (10-100 μg/mL; 12-36 h) produces a drastic increase in chromosome damage in human lymphocytes and in CHO cells[1]. CP-67015 inhibits supercoiling activity of prokaryotic DNA gyrase, with 100% inhibition at the concentration of 4.0 μg/mL[1].

[In Vivo]

CP-67015 (a single dose 1000 mg/kg or 500 mg/kg/day for 5 days; i.p.) induces chromosome damage in male CD-1 mice in mouse bone marrow cells[1].

[References]

[1]. Holden HE, et, al. Genetic profile of a nalidixic acid analog: a model for the mechanism of sister chromatid exchange induction. Environ Mol Mutagen. 1989;13(3):238-52.

Chemical & Physical Properties

[ Density]:
1.424g/cm3

[ Boiling Point ]:
496.7ºC at 760 mmHg

[ Molecular Formula ]:
C17H12F2N2O3

[ Molecular Weight ]:
330.28600

[ Flash Point ]:
254.2ºC

[ Exact Mass ]:
330.08200

[ PSA ]:
72.19000

[ LogP ]:
3.05980

[ Vapour Pressure ]:
1.11E-10mmHg at 25°C

[ Index of Refraction ]:
1.604

Safety Information

[ WGK Germany ]:
3

Related Compounds