Tubulin polymerization-IN-38

Names

[ CAS No. ]:
1005192-31-3

[ Name ]:
Tubulin polymerization-IN-38

Biological Activity

[Description]:

Tubulin polymerization-IN-38 a Tubulysin (HY-128914) analogue, is a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerisation and thereby inducing apoptosis. Tubulin polymerization-IN-38 has cytotoxicity against cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Tubulin polymerisation[1]


[In Vitro]

Tubulin polymerization-IN-38 (example 5) exhibits cytotoxicity against L929, SW-480 and KB-3-1 with IC50s of 2.2 ng/mL, 0.35 ng/mL and 1.5 ng/mL, respectively[1].

[References]

[1]. Jonathan A. Ellman, et al. Tubulysin d analogues. WO2009012958A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H50N4O8S

[ Molecular Weight ]:
638.82

Related Compounds