2'-Deoxy-2'-fluoro-4-thiouridine

Names

[ Name ]:
2'-Deoxy-2'-fluoro-4-thiouridine

[Synonym ]:
2(1H)-Pyrimidinone, 1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-3,4-dihydro-4-thioxo-
1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
1-(2-Deoxy-2-fluoro-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone

Biological Activity

[Description]:

2'-Deoxy-2'-fluoro-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₉H₁₁FN₂O₄S

[ Molecular Weight ]:
262.26

[ Exact Mass ]:
262.042358

[ LogP ]:
-0.17

[ Index of Refraction ]:
1.667

[ Storage condition ]:
2-8°C