4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl-

Names

[ Name ]:
4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl-

Biological Activity

[Description]:

2-Amino-1-β-D-arabinofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.89g/cm3

[ Boiling Point ]:
545.7ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₃N₃O₅

[ Molecular Weight ]:
243.22

[ Flash Point ]:
283.8ºC

[ Exact Mass ]:
243.08600

[ PSA ]:
131.82000

[ Vapour Pressure ]:
3.5E-14mmHg at 25°C

[ Index of Refraction ]:
1.756

4(1H)-Pyrimidinone,2-amino-1-b-D-arabinofuranosyl-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds