DPCPX

Names

[ Name ]:
DPCPX

[Synonym ]:
8-Cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione
MFCD00055117

Biological Activity

[Description]:

DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

Ki: 0.46 nM (3H-CHA binding to A1 receptors in rat whole brain membranes); 340 nM (3H-NECA binding to A2 receptors in rat striatal membranes)[2].

[In Vivo]

DPCPX (PD 116948) ( 0.1, 0.3 and 1.0 mg/kg i.v. ) produces significant dose-related increases (P<0.05) in urine volume and in urinary sodium, potassium and chloride excretion[3].

[References]

[1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61.

[2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63.

[3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97(Suppl): 496P–535P.

Chemical & Physical Properties

[ Density]:
1.195g/cm3

[ Boiling Point ]:
535.1ºC at 760mmHg

[ Melting Point ]:
178°C

[ Molecular Formula ]:
C₁₆H₂₄N₄O₂

[ Molecular Weight ]:
304.38700

[ Flash Point ]:
277.4ºC

[ Exact Mass ]:
304.19000

[ PSA ]:
72.68000

[ LogP ]:
2.36390

[ Appearance of Characters ]:
solid | white

[ Vapour Pressure ]:
1.59E-11mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
Store at RT

[ Stability ]:
Store tightly sealed at RT; Solutions at 4 deg C for several days

[ Water Solubility ]:
DMSO: >10 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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