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Oleracein E

Names

[ CAS No. ]:
1021950-79-7

[ Name ]:
Oleracein E

[Synonym ]:
Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy-
8,9-Dihydroxy-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one
Trolline
MFCD22690448

Biological Activity

[Description]:

(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Bai F, et, al. Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy. Cell Physiol Biochem. 2017;44(2):436-446.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
486.2±45.0 °C at 760 mmHg

[ Melting Point ]:
245-247 °C

[ Molecular Formula ]:
C12H13NO3

[ Molecular Weight ]:
219.24

[ Flash Point ]:
247.9±28.7 °C

[ Exact Mass ]:
219.089539

[ LogP ]:
-0.19

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.698

Related Compounds