PARP10-IN-2

Names

[ Name ]:
PARP10-IN-2

Biological Activity

[Description]:

PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

human PARP10:3.64 μM (IC50)

human PARP15:11 μM (IC50)

human PARP2:27 μM (IC50)

human PARP12:>10 μM (IC50)

human PARP16:>10 μM (IC50)

human PARP1:>100 μM (IC50)

human PARP3:>100 μM (IC50)

human PARP4:>100 μM (IC50)

human TNKS1:>100 μM (IC50)

human TNKS2:>100 μM (IC50)

human PARP14:>100 μM (IC50)

[In Vitro]

PARP10-IN-2 (化合物 10) 在 HeLa-PARP10 细胞中通过克隆形成测定 (CFA) 的 IC50 为 1-2 μM[1]。

[References]

[1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₀N₂O₂

[ Molecular Weight ]:
238.24

PARP10-IN-2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds