5'-DMT-5-I-2'-dU

Names

[ Name ]:
5'-DMT-5-I-2'-dU

[Synonym ]:
5'-O-DMTr-IUdR
5-iodo-5'-DMT-2'-deoxyuridine
2'-Deoxy-5'-O-DMT-5-iodouridine
5'-DMT-5-I-2'-dU

Biological Activity

[Description]:

5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.60±0.1 g/cm3(Predicted)

[ Melting Point ]:
>128 °C (decomp)

[ Molecular Formula ]:
C₃₀H₂₉IN₂O₇

[ Molecular Weight ]:
656.46

[ Exact Mass ]:
656.10200

[ PSA ]:
112.01000

[ LogP ]:
3.81550

[ Storage condition ]:
2-8℃

5'-DMT-5-I-2'-dU

Names

Biological Activity

Chemical & Physical Properties

Related Compounds