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Palifosfamide tromethamine

Names

[ CAS No. ]:
1070409-31-2

[ Name ]:
Palifosfamide tromethamine

[Synonym ]:
ZIO-201-T
UNII-0X5A3C04ID
Palifosfamide tromethamine

Biological Activity

[Description]:

Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

[References]

[1]. Jones B, Komarnitsky P, Miller GT, Amedio J, Wallner BP. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012;23(2):173-184.

Chemical & Physical Properties

[ Molecular Formula ]:
C8H22Cl2N3O5P

[ Molecular Weight ]:
342.15700

[ Exact Mass ]:
341.06700

[ PSA ]:
157.88000


Related Compounds