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Anwulignan

Names

[ CAS No. ]:
107534-93-0

[ Name ]:
Anwulignan

[Synonym ]:
Phenol, 4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-
HMS2219A18
(+)-Anwulignan
Macelignan
4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol
UNII-8PP3614Z43
austrobailignan 6
Anwuligan
Macelignan, (+)-

Biological Activity

[Description]:

Macelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.IC50 value:Target: in vitro: Macelignan significantly attenuated the ROS production and neurotoxicity induced by glutamate in HT22 cell [1]. At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min [2]. Cisplatin-induced phosphorylation of c-Jun N-terminal kinase1/2 (JNK1/2) and extracellular signal-regulated kinase1/2 (ERK1/2) was abrogated by pretreatment with macelignan, however, that of p38 was not significantly affected [3].in vivo: Macelignan attenuated the expression of phosphorylated c-Jun in cisplatin-treated mice [3]. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions [4].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease
Natural Products >> Phenylpropanoids

[References]

[1]. Jin DQ, et al. Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1264-9.

[2]. Yanti, et al. In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria. Phytother Res. 2008 Mar;22(3):308-12.

[3]. Sohn JH, et al. Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biol Pharm Bull. 2008 Feb;31(2):273-7.

[4]. Cui CA, et al. Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats. Neurosci Lett. 2008 Dec 19;448(1):110-4.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.159

[ Boiling Point ]:
467.0±40.0 °C at 760 mmHg

[ Melting Point ]:
70-71℃

[ Molecular Formula ]:
C20H24O4

[ Molecular Weight ]:
328.402

[ Flash Point ]:
236℃

[ Exact Mass ]:
328.167450

[ PSA ]:
47.92000

[ LogP ]:
5.22

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.574

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29329990

Articles

Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats.

Neurosci. Lett. 448(1) , 110-4, (2008)

Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hip...


More Articles


Related Compounds