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ac-93253 iodide

Names

[ CAS No. ]:
108527-83-9

[ Name ]:
ac-93253 iodide

Biological Activity

[Description]:

AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT1:45.3 μM (IC50)

SIRT2:6 μM (IC50)

SIRT3:24.6 μM (IC50)


[In Vitro]

AC93253 可抑制 SIRT1、SIRT2 和 SIRT3，IC50 值分别为 45.3 μM、6 μM 和 24.6 μM[1]。 AC-93253（0、2、5、10 μM；16 h）显著增强微管蛋白、p53 和组蛋白 H4 的乙酰化[1]。 AC-93253 对四种肿瘤细胞系表现出选择性细胞毒性，IC50 值范围为 10 - 100 nM[1]。 AC-93253 显著触发细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: NCI-H460 cells, HeLa cells Concentration: 0, 2, 5, 10 μM Incubation Time: 16 h Result: Increased the acetylation levels of a-tubulin in a dose-dependent manner. Increased the level of histone protein and p53.

[References]

[1]. Zhang, Yingjia et al. Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity. Biochemical and biophysical research communications vol. 386,4 (2009): 729-33.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H25IN2S

[ Molecular Weight ]:
488.42700

[ Exact Mass ]:
488.07800

[ PSA ]:
35.36000

[ LogP ]:
2.60240

MSDS

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Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds